Eiira Classic Genetic Test Kit for Hereditary Cancer Risk

Eiira genetic test profiles - how it works

Eiira Classic

4990 kr

A genetic test to prevent hereditary cancer Simple genetic test done at home Discover hereditary risks for the 10 most common cancers Take preventive action

Out of stock

Set-up fee SEK 0, administrative fee SEK 0/month, fixed annual interest rate 18.9%. 1) Effective interest rate 20.6%. The total amount includes the calculated credit amount of SEK 526 for Eiira Classic. Applies to a 12-month installment with Klarna. 2) Effective interest rate 20.5%. The total amount includes the calculated credit amount of SEK 279 for Eiira Classic. Valid for 6 months installment with Klarna. Credit provider and payee: Klarna Bank AB (publ) Sveavägen 46, 111 34 Stockholm. Amounts stated are an indication. Exact cost varies depending on the day of the month the purchase is made. For full terms and conditions, read more at klarna.com/en/terms.

Yes, it is easy. We will post a saliva collection kit and a return envelope to your home via Postnord. You simply spit saliva into the collection tube. If you need help, instructions are enclosed in the kit. Once you have collected saliva, you place the kit in the return envelope, which has a paid return label. You can then drop off the envelope at any Postnord service point.

The only other thing you need to do is to provide your details and our family’s medical history. The tools on our website will help you easily input the information. It is okay if you don’t provide your family medical history because you don’t know or you prefer not to.

The risk for 10 cancer types is mapped out by using the proven risk models and reference risk estimation data that are recommended in Swedish national guidelines. The below information is used as input to the mapping:

The results of your genetic tests. You can find more information in the section "What is the technology behind the genetic test?"
Your family medical history. Given the limitation of the current genomic science, your genetic test data alone cannot predict all risks. The family’s medical history contains much hereditary information. In some cases, family history alone can predict hereditary cancer risk. Therefore family medical history is used as part of the input.
Information on you and your medical history. Personal information such as ethnicity and ancestry roots have an impact on our hereditary risks. Your lifestyle and medical history affect the risk level.

Note that the risks we report are hereditary risks. That is the risk that you inherited from your biological parents.

Behind the test is one of the most advanced techniques called Whole Exome Sequence (WES). First, your saliva sample is analysed and all DNA from the germ cells responsible for generating your proteins is captured. 'Germinal' means only the DNA that you inherited from your parents at fertilisation. The analysis then looks for any pathogenic gene changes (known as variants) in the DNA data (i.e. your entire exome data).

Our report includes 50 genes that are known to cause a significantly increased risk of developing cancer. The selection of these 50 genes is based on Swedish national guidelines.

Because germline DNA remains the same during a person’s lifetime, you do not need to take another genetic test for your whole exome data. As genomic science and cancer prevention measures are constantly being discovered, you can enjoy these new advancements without taking another test.

First of all, we need to understand that the risk is the likelihood of developing cancer:

Risk is not a diagnosis.
Some people with high risk never have cancer.
Similarly, people with low risk can still develop cancer.

Second, there are preventive measures to empower you. The report will inform you of proactive options available in Sweden. For many cancers, over 90% (close to 100% for breast cancers) survive if discovered early. The healthcare system has a number of monitoring programs to discover cancers early. We’ll inform you how to enter the Swedish healthcare system. There are also preventive healthcare partners that we can recommend to you.

Genes associated

To make this assessment, we have analyzed 50 genes in your DNA to identify the possible presence of disease-causing variants that are linked to an increased cancer risk. These genes have been selected based on their association with certain specific cancers or cancer syndromes. The table below shows the genes linked to the 10 different cancers covered by the analysis (i.e. the genes where we know that people carrying a disease-causing variant have an increased risk of cancer).

Cancer type	Genes associated
Breast	BRCA1, BRCA2, PALB2, TP53, PTEN, CDH1, STK11, NF1, ATM, CHEK2, BARD1, RAD51C, RAD51D
Ovarian	BRCA1, BRCA2, PALB2, RAD51C, RAD51D, BRIP1, MLH1, MSH2, EPCAM, MSH6, PMS2
Colon	MLH1, MSH2, MSH6, PMS2, EPCAM, APC, MUTYH, STK11, SMAD4, BMPR1A, PTCH, PTEN, NTHL1, POLD1, POLE, MSH3, TP53
Prostate	BRCA2, HOXB13, BRCA1, MLH1, MSH2, MSH6, EPCAM, PMS2, ATM, CHEK2, PALB2, TP53
Melanoma	CDKN2A, BAP1, CDK4, POT1, TERT, MITF1, MC1R, ASIP, TYR, TYRP1, TP53
Kidney/Renal	VHL, FLCN, FH, MET, PTEN, SDHB, BAP1, SDHA, SDHC, SDHD
Thyroid	RET, APC, PTEN, DICER1, TP53
Uterine	MLH1, MSH2, MSH6, PMS2, PTEN
Pancreatic Cancer	BRCA1, BRCA2, ATM, PALB2, MLH1 , MSH2, EPCAM, MSH6, PMS2, STK11, CDKN2A
Hereditary diffuse gastric cancer	CDH1, CTNNA1

How it works

1. Collect saliva at home

We’ll post you a saliva collection kit right to your doorstep. Simply collect the saliva and return it to us using the provided prepaid envelope.

2. Tell us about you

With our web tool, you can enter your information, including details about your family if desired. These inputs will be used to map out your genetic risks.

3. Get your profile

Download your profile report. In the case of a high risk, you have the option to consult with a genetic counsellor for further guidance

4. Stay updated

You can choose to stay updated on the latest risk mapping and preventive measures resulting from new discoveries in genetic science.

Compare Eiira Classic and Premium

Features	Eiira Classic	Eiira Premium
Risk mapping for the ten most common cancers	✅	✅
Preventive measure for ten most common cancers	✅	✅
Updates for ten most common cancers	✅	✅
Future updates to cover other diseases	Limited	Unlimited
Lifetime updates of the latest discoveries in genetic science	Limited	Unlimited
Possibility to detect rare cancer variants	⭐⭐⭐⭐ (medium)	⭐⭐⭐⭐⭐ (most)
Genetic Sequencing Technology	Whole exome sequencing (WES)	Whole Genome Sequencing (WGS)
Choose your Eiira genetic test:	4990 kr	9990 kr